Hidden Bibliographic Details
| Other authors / contributors: | Alessio, Enzo.
Ang, Wee Han.
Babak, Maria V.
Berners-Price, Susan.
Brabec, Victor.
Casini, A.
Farrell, Nicholas P.
Freisinger, Eva, editor.
Gorle, Anil K.
Kasparkova, Jana.
Lippard, Stephen J.
Menon, Vijay.
Messori, Luigi.
Peterson, Erica J.
Riddell, Imogen.
Sadler, Peter J.
Sigel, Astrid, editor.
Sigel, Helmut, editor.
Sigel, Roland K. O., editor.
Venkatesh, V.
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| ISBN: | 9783110470734
311047073X
9783110470741
3110470748
3110469901
9783110469905
9783110469844
3110469847
9783110469905
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| Digital file characteristics: | text file PDF
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| Notes: | Includes bibliographical references and index.
In English.
Online resource; title from PDF title page (publisher's Web site, viewed 19. Feb 2018).
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| Summary: | Volume 18 centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.
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| Other form: | EPUB 9783110469905
Print version: 9783110469844
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| Standard no.: | 10.1515/9783110470734
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